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. 2021 May 20;9:669696. doi: 10.3389/fcell.2021.669696

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Copyright © 2021 Deng, Fu, Sheng, Hu, Su, Luo, Yan and Chi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pyroptosis and apoptosis are induced sequentially by ischemia–reperfusion in retina and cultured microglia. (A,B) Western blot analysis showing induction of pyroptosis and apoptosis markers in retinal tissue following RIR (n = 3). (C,D) Western blot analysis showing upregulation of pyroptosis and apoptosis markers in BV2 microglia following OGDR (n = 3). (E) Dual immunofluorescence staining of retina showing induction of the pyroptosis markers GSDMD in retinal microglia following RIR (Scale bar: 50 μm, Magnification: ×400). I/R, retinal ischemia–reperfusion; OGDR, oxygen-glucose deprivation and reperfusion. *P < 0.05, **P < 0.01. One-way ANOVA with post hoc Bonferroni tests was applied.