Table 2.
Subgroup analysis between LGGs, mixed-grade gliomas, and HGGs; between static PET scan and dynamic PET scan; and between visual assessment of the PET scan and semi-quantitative parametric analysis.
| Radiotracer and parameter | Subgroup | Number of studies/PET scan tests | Pooled Sen and its 95%CI | P-value | Pooled Spe and its 95%CI | P-value | Pooled DOR and its 95%CI | AUC | |
|---|---|---|---|---|---|---|---|---|---|
| 18F-FET, TBRmax | HGGs | 6/333 | 0.92 (0.85,0.98) | 0.51 | 0.88 (0.79,0.96) | 0.90 | 75 (18,304) | 0.92 | 0.04 |
| Gliomas of mixed grades | 8/477 | 0.84 (0.75,0.93) | 0.71 (0.61,0.81) | 12 (6,23) | 0.80 | ||||
| Static scan | 5/311 | 0.94 (0.88,0.99) | 0.80 | 0.76 (0.62,0.90) | 0.09 | 47 (7,299) | 0.92 | 0.10 | |
| Dynamic scan | 9/810 | 0.82 (0.73,0.91) | 0.79 (0.71,0.88) | 15 (7,32) | 0.86 | ||||
| PET performed ≤7d after SRR | 3/108 | 0.84 (0.76,0.92) | 0.19 | 0.79 (0.56,1.00) | 0.64 | NA | NA | 0.34 | |
| PET performed >7d after SRR | 4/233 | 0.76 (0.68,0.84) | 0.82 (0.68,0.95) | NA | NA | ||||
| 18F-FDG | Visual assessment | 8/355 | 0.76 (0.63,0.85) | 0.30 | 0.90 (0.81,0.95) | <0.05 | 29 (14,60) | 0.92 | 0.17 |
| Semi-quantitative parametric analysis | 7/349 | 0.83 (0.73,0.90) | 0.82 (0.72,0.89) | 23 (10,51) | 0.85 | ||||
| HGGs | 11/214 | 0.76 (0.68,0.83) | 0.82 (0.70,0.90) | 15 (7,33) | 0.84 | ||||
| Gliomas of mixed grades | 7/417 | 0.76 (0.58,0.88) | 0.31† | 0.87 (0.80,0.92) | <0.05† | 21 (8,52) | 0.88 | 0.64† | |
| LGGs | 5/141 | 0.61 (0.34,0.83) | 0.83† | 0.90 (0.77,0.96) | 0.02† | 15 (3,88) | 0.90 | 0.10† | |
| 11C-MET, TBR | HGGs | 3/248 | 0.94 (0.87,1.00) | 0.95 | 0.82 (0.69,0.95) | 0.47 | 71 (20,251) | 0.95 | 0.58 |
| Gliomas of mixed grades | 4/384 | 0.89 (0.78,0.99) | 0.77 (0.67,0.86) | 29 (7, 117) | 0.79 | ||||
| PET performed <20 m after RT | 2/92 | 0.96 (0.91,1.00) | 0.89 | 0.71 (0.53,0.89) | 0.04 | NA | NA | 0.11 | |
| PET performed >20 m after RT | 4/110 | 091 (0.84,0.97) | 0.89 (0.79,0.99) | NA | NA | ||||
| 18F-DOPA | Visual assessment | 3/175 | 0.86 (0.80,0.92) | <0.05 | 0.72 (0.59,0.86) | 0.22 | 16 (4,62) | 0.93 | 0.8 |
| Semi-quantitative analysis of TBRmax | 3/175 | 0.84 (0.77,0.90) | 0.68 (0.54,0.83) | 14 (4,50) | 0.85 |
AUC, area under receiver operating curve; CI, confidence interval; DOR, diagnostic odds ratio; HGGs, high-grade gliomas; LGGs, low-grade gliomas; SRR, suspicious recurrence of glioma; TBR, tumor-to-brain ratio. Bold face type indicates statistical significance. *Based on meta regression.
†
Compared with group of HGGs.