TABLE 4.

Network markers of the highest degree.

	Gene Index	Gene Symbol	Degree	Function	References
AD	cg09414535	GRIP1	945	GRIP1 mediates synaptic and non-synaptic signals. It plays an important role in the development and function of oligodendrocytes and their precursors in vivo	Kula et al., 2019
PD	cg11672225	RNF185	2478	(1) E3 ubiquitin ligase regulates selective mitochondrial autophagy by mediating “lys-63” linked multi ubiquitination of BNIP1	Tang et al., 2011; Kaneko et al., 2016
				(2) Plays a role in the endoplasmic reticulum related degradation pathway, which targets misfolded proteins accumulated in the endoplasmic reticulum for ubiquitination and subsequent proteasome mediated degradation, and protects cells from endoplasmic reticulum stress-induced apoptosis
PSP	cg14448116	GPR21	720	A constitutively active receptor that can be coupled with Gαq type G protein, leading to the activation of mitogen activated protein kinase, thus inducing cell senescence, growth arrest, and cell death	Anerillas et al., 2020
FTD	cg15784615	LTBR	706	(1) Promoting apoptosis through TRAF3 and TRAF5	Crowe et al., 1994; Keats et al., 2007
				(2) Leading to constitutive activation of the non-canonical NF-κB pathway, which is involved in cellular immune response, growth control, and apoptosis
ND	cg09414535	GRIP1	1114	Acting as local scaffolds for the assembly of multi protein signaling complexes and mediators for the transport of their binding partners at specific subcellular locations of neurons	Dong et al., 1997