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. 2021 May 20;12:682120. doi: 10.3389/fimmu.2021.682120

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Copyright © 2021 Paquin-Proulx, Gunn, Alrubayyi, Clark, Creegan, Kim, Kibuuka, Millard, Wakabi, Eller, Michael, Schoepp, Hepburn, Hensley, Robb, Alter and Eller

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Elevated plasma levels of pro-inflammatory soluble factors in BDBV survivors with hearing loss. Plasma levels of 53 soluble factors were measure by Luminex and results were compared between BDBV survivors with or without long term sequalae. Significant differences are shown for IL-1β, IL-2, IL-6, IL-7, IL-10, IL-12p70, IL-17a, IL-23, IFNγ, Fractalkine, MIP1α, sIL-6Ra, MMP-3, and APRIL for hearing loss as well as Pentraxin 3 and MMP-1 for eye pain and blurred vision respectively. The line and whiskers represent the median and interquartile range respectively. ** represents p values < 0.01 and * represents p values < 0.05.