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. 2021 May 20;11:646060. doi: 10.3389/fonc.2021.646060

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Copyright © 2021 Huang, Zhang, He, Ji, Gao, Liu, Wang, Liu and Xin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screening target genes. (A) The network of top 50 hub genes screened by CytoHubba Stress algorithm. (B) The network of top 50 hub genes screened by CytoHubba Betweenness algorithm. Node size indicated its connectivity (the larger the node, the more proteins interacted). Node color indicated gene ranking (top-ranked genes colored by relatively darker color). (C) Forest plot showing hazard ratios with p‐values and 95% CI measured by univariate Cox regression analysis. The dashed line marked hazard ratio=1. Red boxes represented unfavorable prognosis genes, and blue boxes remarked favorable prognosis genes. CI, confidence interval. (D) Venn plots showing the intersected genes between hub genes and survival-related genes.