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. 2021 May 20;12:627986. doi: 10.3389/fimmu.2021.627986

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Copyright © 2021 Grönwall, Liljefors, Bang, Hensvold, Hansson, Mathsson-Alm, Israelsson, Joshua, Svärd, Stålesen, Titcombe, Steen, Piccoli, Sherina, Clavel, Svenungsson, Gunnarsson, Saevarsdottir, Kastbom, Serre, Alfredsson, Malmström, Rönnelid, Catrina, Lundberg and Klareskog

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reactivity to acetylated acetylated histone 2B. Serum IgG reactivity to acetylated histone 2B (K12) was determined by ELISA in 437 population controls, 160 SLE patients, 403 RA patients whereof 125 CCP2 negative and 278 CCP2 positive, and 267 CCP2 positive RA-risk individuals without arthritis. Reactivity to the acetylated (KAc) peptide (A) was compared to the native (lys) peptide (B). (C, D) show acetylation reactivity normalized for native reactivity, Δac-lys His2B. Red lines depict medians. P-values are presented from Kruskal-Wallis test with Dunn’s correction for multiple comparisons. Positivity for Δac-lys His2B was set based on mean + 3SD for 316 population controls (4.25 AU/ml).