Table 1.
AMPA reactivities in RA patients.
| Controls | SLE | RA-Risk | All RA | CCP-RA | CCP+ RA | |
|---|---|---|---|---|---|---|
| AMPA frequencies | ||||||
| CCP2 IgA | N/A | N/A | N/A | 45% (882/1942) | 8% (59/729) | 68% (823/1213) |
| Δac-lys His2B [>4.25 AU/ml]* | 0% (0/437) | 3.8% (6/160) | 12.7% (34/267) | 17% (68/403) | 2.4% (3/125) | 23% (65/278) |
| mod-Vim IgG Cit [OD>0.55]# | 2.9% (14/480) | N/A | N/A | 60% (1188/1982) | 11% (84/733) | 88% (1104/1249) |
| mod-Vim IgG Orn(Ac) [OD>0.55]# | 2.7% (13/480) | N/A | N/A | 51% (1007/1982) | 7.6% (56/733) | 76% (951/1249) |
| mod-Vim IgG Carb [OD>0.69]# | 2.7% (13/480) | N/A | N/A | 41% (809/1982) | 6% (44/733) | 61% (765/1249) |
| mod-VimIgG Lys(Ac) [OD>0.68]# | 2.9% (14/480) | N/A | N/A | 29% (571/1982) | 4.4% (32/733) | 43% (539/1249) |
| mod-Vim IgA Cit [OD>0.32]€ | 0.6% (3/480) | N/A | N/A | 17% (333/1982) | 1.2% (9/733) | 26% (324/1249) |
| mod-Vim IgA Orn(Ac) [OD>0.36]€ | 0.6% (3/480) | N/A | N/A | 10% (199/1982) | 2.2% (16/733) | 15% (183/1249) |
| mod-Vim IgA Carb [OD>0.48]€ | 0% (0/480) | N/A | N/A | 5.8% (115/1982) | 2.9% (21/733) | 7.5% 94/1249) |
| mod-Vim IgA Lys(Ac) [OD>0.36]€ | 0.2% (1/480) | N/A | N/A | 7.5% (149/1982) | 1.9% (14/733) | 11% (135/1249) |
| Carb-Fib IgG [>23 AU/ml]§ | 2.5% (8/316) | N/A | N/A | 43% (844/1982) | 12% (90/730) | 60% (754/1255) |
| Carb-FCS IgG [>232 AU/ml]§ | 3.1% (10/316) | N/A | N/A | 36% (705/1982) | 12% (85/730) | 49% (621/1255) |
| MAA IgG [high >56.44 AU/ml]** | 14% (61/437) | 44% (70/159) | 13% (39/267) | 44% (176/403) | 33% (41/125) | 49% (135/278) |
| AMPA levels mean±SD (median) | ||||||
| KAc-His2B IgG | 1.4±3.1 (0.53) | 5.2±9.4 (1.4) | 5.0±7.7 (1.6) | 4.4±9.0 (0.84) | 1.2±2.4(0.46) | 5.9±10 (1.5) |
| Δac-lys His2B IgG | -0.11±1.4 (0.01) | -1.2±4.2 (-0.25) | 2.0±6.1 (0.20) | 3.2±8.6 (0.10) | 0.29±1.5 (-0.001) | 4.5±10 (0.36) |
| mod-Vim IgG Cit | 0.18±0.31 (0.08) | N/A | N/A | 1.6±1.4 (1.3) | 0.33±0.57 (0.17) | 2.4±1.2 (2.7) |
| mod-Vim IgG Orn(Ac) | 0.21±0.26 (0.15) | N/A | N/A | 1.2±1.1 (0.57) | 0.29±0.24 (0.21) | 1.6±1.1 (1.5) |
| mod-Vim IgG Carb | 0.19±0.26 (0.13) | N/A | N/A | 0.89±0.93 (0.49) | 0.28±0.31 (0.20) | 1.3±1.0 (0.95) |
| mod-Vim IgG Lys(Ac) | 0.16±0.22 (0.11) | N/A | N/A | 0.70±0.82 (0.35) | 0.27±0.27 (0.20) | 0.94±0.93 (0.55) |
| mod-Vim IgA Orn(Ac) | 0.07±0.05 (0.05) | N/A | N/A | 0.21±0.29 (0.14) | 0.16±0.15 (0.14) | 0.24±0.34 (0.14) |
| mod-Vim IgA Carb | 0.07±0.05 (0.06) | N/A | N/A | 0.19±0.22 (0.13) | 0.16±0.17 (0.13) | 0.20±0.24 (0.14) |
| mod-Vim IgA Lys(Ac) | 0.07±0.05 (0.06) | N/A | N/A | 0.18±0.24 (0.12) | 0.13±0.14 (0.11) | 0.21±0.27 (0.13) |
| Carb-Fib IgG | 3.6±11 (0.31) | N/A | N/A | 75±210 (17) | 21±106 (4.7) | 107±246 (33) |
| Carb-FCS IgG | 56±140 (22) | N/A | N/A | 311±448 (137) | 114±218 (52) | 425±504 (229) |
| MAA IgG | 33.7±27 (26) | 65±47 (48.3) | 36±26 (27) | 62±39 (49.8) | 54±39 (43) | 65±39 (55) |
*Mean of 316 controls + 3SD; **85th percentile of 317 controls; #97th percentile of 480 controls.
§Mean of 316 controls + 2SD; €97th percentile of 480 controls x2.
Values for control assays are available in Supplemental Table 2 .