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The Pathological Deposition of Tau Protein in Alzheimer’s Disease. (A) The Phosphorylation (denoted with “P”) of tau protein is associated with the destabilization of the tau microtubule complex and the assembly of tau protein into higher order aggregates. (B) Mature tau fibrils (in blue, darker color denotes greater fibril density) spreads throughout the brain of AD patients in discrete stages which resembles the progression of communicable prion diseases.
