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. 2021 May 20;8:671458. doi: 10.3389/fmolb.2021.671458

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Copyright © 2021 Mah, Zhao, Liu, Zhang, Liu, Wang, Linhardt and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Binding of Tau to Defined 3-O Sulfated Glycans as Measured by NMR. (A) An overlay of two ¹H-¹⁵N heteronuclear single quantum coherence spectra of full-length tau before (blue) and after 1:0.6 molar ratio addition of a 3-O sulfated HS oligosaccharide (oligo-4, green) and an otherwise identical oligosaccharide lacking a 3-O sulfo group (oligo-5, red). (B) Zoomed-in NMR spectra of residues with the largest Chemical Shift Perturbation (CSP). (C) The Comparison CSP differences of the two oligosaccharides (ACSP) reveals specific interaction between 3-0-S and tau in the residues of the PRR2 and MTBR domains of tau 441. A Domain map of tau is shown above the figure. PRR, proline-rich region; MTBR, microtubule binding repeat. Adapted from Zhao et al. (2017, 2020).