Table 1.
Studies reporting acute pericarditis in patients with SARS-CoV-2 infection
| Study | Year/country | Age/gender | Presentation | Cardiac enzymes | ECG | TTE | CMR | Other | Management | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|
| Amoozgar et al. [26] | 2020/USA | 56/male | Chest pain and dyspnea | NL | Atrial fibrillation | Large circumferential pericardial effusion | N/A | Cardiomegaly on CXR | Pericardial window + ibuprofen | Resolution |
| Ortiz-Martinez et al. [42] | 2020/Columbia | 25/male | Chest pain and dyspnea | NL | Sinus rhythm | Pericardial effusion | N/A | Pericardial effusion on CT | Ibuprofen and colchicine + morphine/oxycodone | Improvement |
| Asif et al. [44] | 2020/USA | 70/female | Chest pain, dyspnea, myalgia | NL | Diffuse ST elevation and PR depression | Circumferential pericardial effusion/+tamponade physiology | N/A | Cardiomegaly on CXR | Pericardiocentesis and colchicine | Resolution |
| Fox et al. [45] | 2020/USA | 43/male | Chest pain, orthopnea, dyspnea | NL | Diffuse ST elevation and PR depression | Circumferential pericardial effusion/+tamponade physiology | N/A | Cardiomegaly on CXR | Pericardiocentesis and ibuprofen + colchicine | Resolution |
| Walker et al. [46] | 2020/USA | 30/female | Chest pain, fever, cough, shortness of breath | NL | Sinus tachycardia | Moderate pericardial effusion | N/A | Pericardial effusion on CT | Pericardial window + colchicine initially and aspirin added at day 7 | Improvement |
| Blagojevic et al. [47] | 2020/Serbia | 51/male | Chest pain | NL | ST elevation and PR depression | Pericardial effusion and hyperechogenic pericardium | N/A | N/A | Aspirin, beta blocker, lopinavir/ritonavir, ceftrioxone | Resolution |
| Sauer et al. [48] | 2020/France | 51/male | Chest pain, dyspnea | Anterolateral ST-elevation and low QRS voltage | N/A | Circumferential pericardial LGE | Polyserositis on chest CT | Pericardiocentesis + colchicine | Resolution | |
| Kumar et al. [49] | 2020/Ireland | 66/male | Chest pain | NL | ST elevations in most leads and PR depression | Pericardial brightening (thickened?) | Pericardial thickening on CMR | Normal | Colchicine | Resolution |
| Dabbagh et al. [50] | 2020/USA | 57/male | Cough, shortness of breath, left shoulder pain | NL | Non-specific ST changes | Circumferential pericardial effusion/+tamponade physiology | N/A | Cardiomegaly on CXR | Pericardiocentesis and hydroxychlorquine + colchicine + glucocorticoids | Serial ECHO and troponins concerning for Takotsubo cardiomyopathy that resolved eventually |
| Tung-Chen et al. [51] | 2020/Spain | 35/female | Chest pain, cough, malaise, fever, anosmia | NL | T wave inversions | Pericardial effusion | N/A | N/A | Colchicine | Resolution |
| Karadeniz et al. [52] | 2020/Turkey | 33/male | Chest pain | N/A | Non-specific | Circumferential pericardial effusion | N/A | Pericardial effusion on chest CT | Hydroxychlorquine and indomethacin + colchicine. Anakinra added at day 5 | Resolution |
| Raymond et al. [53] | 2020/ USA | 7/female | Chest pain, cough, orthopnea | NL | Sinus tachycardia and low voltage QRS with electrical alternans | Large circumferential pericardial effusion | Enlarged cardiac silhouette with pleural effusions | N/A |
Pericardiocentesis and NSAIDS + colchicine. Pericardiectomy was done eventually |
Worsening symptoms leading to pericardiectomy and no follow-up available after surgery |
| Ashwin et al. [54] | 2020/UK | 63/female | Chest pain | NL | ST segment elevation and PR depression in inferolateral leads | Large pericardial effusion (four days later) | N/A | Pericardial thickening with no pericardial effusion on CT (baseline) | Pericardiocentesis and NSAID + colchicine | Developed pericardial effusion and then complete resolution |
ECG electrocardiogram, TTE transthoracic echocardiogram, CMR cardiac magnetic resonance imaging, CXR chest X-ray, NL normal, YO year old