Table 2.
|
Severe dysbiosis (n = 24)
|
Non-severe dysbiosis (n = 24)
|
P
value
|
Age, yr | 51.5 (42.0-59.0) | 50.0 (35.0-57.5) | 0.392 |
Body mass index, kg/m2 | 24.6 (22.8-27.7) | 24.2 (22.7-27.7) | 0.837 |
Male/female | 12/12 | 11/13 | 0.500 |
Etiology of cirrhosis: Alcohol | 9 | 9 | 0.617 |
Autoimmune | 2 | 7 | 0.068 |
HBV | 7 | 2 | 0.068 |
HCV | 5 | 3 | 0.350 |
Cryptogenic | 1 | 3 | 0.304 |
Child–Turcotte–Pugh score | 9 (8-10) | 7 (6-9) | 0.047 |
Death | 13 | 3 | 0.001 |
Death within the first year of follow-up | 5 | 2 | 0.092 |
Death during the following years of follow-up | 8 | 1 | 0.002 |
Esophageal varices (present/absent) | 20/4 | 18/6 | 0.477 |
Hepatic encephalopathy (overt/minimal/absent) | 11/9/4 | 6/11/7 | 0.288 |
Number connection test, seconds | 87 (65-118) | 79 (59-92) | 0.248 |
Ascites (present/absent) | 16/8 | 11/13 | 0.122 |
Spontaneous bacterial peritonitis (present/absent) | 0/24 | 0/24 | 1.000 |
Red blood cells, 1012 cell/L | 3.8 (3.4-4.0) | 3.9 (3.6-4.5) | 0.370 |
White blood cells, 109 cell/L | 3.8 (2.7-5.3) | 3.8 (3.1-5.2) | 0.628 |
Platelets, 109 cell/L | 87 (55-120) | 76 (60-108) | 0.860 |
Serum total protein, g/L | 70 (61-76) | 73 (64-78) | 0.599 |
Serum albumin, g/L | 31 (28-37) | 38 (34-41) | 0.009 |
Serum total bilirubin, μmol/L | 47 (31-62) | 31 (24-63) | 0.375 |
Prothrombin index (Quick test), % | 58 (48-67) | 64 (54-71) | 0.239 |
Creatinine, mg/dL | 0.69 (0.53-0.87) | 0.73 (0.66-0.90) | 0.187 |
Serum sodium, mmol/L | 141 (139-144) | 141 (138-143) | 0.795 |
Serum potassium, mmol/L | 4.3 (4.0-4.7) | 4.3 (4.1-4.7) | 0.844 |
Serum glucose, mmol/L | 5.1 (4.7-5.6) | 5.3 (4.7-6.0) | 0.260 |
Alanine aminotransferase, U/L | 36 (25-72) | 37 (23-60) | 0.804 |
Aspartate aminotransferase, U/L | 54 (41-98) | 40 (26-67) | 0.219 |
Gamma glutamyl transferase, U/L | 77 (40-148) | 76 (36-131) | 0.621 |
Alkaline phosphatase, U/L | 221 (188-340) | 222 (166-298) | 0.542 |
Cholinesterase, kU/L | 2.7 (1.9-3.7) | 4.0 (3.6-4.5) | 0.031 |
C-reactive protein, mg/L | 10.1 (2.1-16.1) | 2.1 (0.3-8.9) | 0.032 |
Splenic length, cm | 15.4 (14.0-17.6) | 16.1 (13.3-19.2) | 0.841 |
HBV: Hepatitis B virus; HCV: Hepatitis C virus.