FIGURE 2.
Spatially resolved gene expression of embryonic livers. (A,B) The MIA map of all scRNA-seq-identified cell types and ST-defined regions in 8 PCW (A) and 17 PCW liver (B). The numbers of cell type- and tissue region-specific genes used in the calculation are shown. Red indicates enrichment (significantly high overlap); blue indicates depletion (significantly low overlap). (C) Venn diagram showing the overlaps of specifically expressed genes of hepatocyte and Endothelial cells between ST and scRNA-seq data. (D,E) The spots visualized at their original positions in the 8 PCW live tissue (D), and the 17 PCW live tissue (E). The colors indicate the clusters each spot is assigned to in the t-SNE plot in Figures 1A,B.