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. 2021 May 20;9:660851. doi: 10.3389/fcell.2021.660851

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Copyright © 2021 Eirin, Meng, Zhu, Li, Saadiq, Jordan, Tang, Lerman, van Wijnen and Lerman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulated miRNA in human ASC-derived EVs and their gene targets. Heat map of miRNAs downregulated in obese-EVs vs. lean-EVs (A). GSEA analysis of the molecular function (B), cellular component (C), and biological process (D) of gene targets of miRNAs upregulated in obese-EVs.