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. 2021 May 20;9:660851. doi: 10.3389/fcell.2021.660851

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Copyright © 2021 Eirin, Meng, Zhu, Li, Saadiq, Jordan, Tang, Lerman, van Wijnen and Lerman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNA sequencing validation. In samples treated with RNAse expression of candidate miRNAs by qPCR followed the same patterns as the original miRNA sequencing findings (without RNAse treatment). hsa-miR-222-5p and has-miR-888-5p, which were upregulated in obese-EVs vs. lean-EVs by miRNA sequencing analysis were also upregulated in obese-EVs vs. lean-EVs treated with RNAse (A). hsa-miR-6752-5p and has-miR-6338-3p, which were downregulated in obese-EVs vs. lean-EVs by miRNA sequencing analysis were also downregulated in obese-EVs vs. lean-EVs treated with RNAse (B). hsa-miR-4648 and has-miR-10a3p, which did not differ between obese-EVs and lean-EVs by miRNA sequencing analysis remained similar in obese-EVs and lean-EVs treated with RNAse (C) (all Student’s t-test). *p < 0.05 vs. Lean-EVs.