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. 2021 Jun 7;27(21):2710–2726. doi: 10.3748/wjg.v27.i21.2710

Table 3.

Main genetic alterations detectable in other pancreatic tumors

Type of pancreatic lesion
Genetic alteration
Reported frequency (%)
Type of alterations
Role in clinical practice
SPN CTNNB1 90-100 Point mutations Diagnostic
PanNET MEN1 70 Point mutations/LOH Diagnostic/prognostic
VHL 25 Point mutations/LOH Diagnostic
AAC CTNNB1 5-25 Point mutationsLOF Diagnostic
MSI 5-15 LOF Predictive?

The percentages quoted are estimated from the literature cited in the paper. Diagnostic role appears mainly in preoperative material. SPN: Solid pseudopapillary neoplasm; PanNET: Pancreatic neuroendocrine tumor; AAC: Acinic adenocarcinoma; LOH: Loss of heterozygosity; LOF: Loss of function.