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. 2021 Jun 7;27(21):2850–2870. doi: 10.3748/wjg.v27.i21.2850

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Comparative analysis of the overlapping transcriptomes mapping to severe coronavirus disease 2019 liver tissue, liver cirrhosis, liver fibrosis, and non-alcoholic fatty liver disease. A: Top 20 Genes overlapping between the upregulated transcriptome of severe coronavirus disease 2019 (COVID-19) patients’ liver tissue samples and the signatures of liver cirrhosis, liver fibrosis, and non-alcoholic fatty liver disease retrieved from DisGeNET; gene disease association score was retrieved from DisGeNET and fold change is calculated using AltAnalyze to represent the difference in expression in COVID-19 liver tissue samples vs non-COVID-19 liver samples; B: functional clustering and pathway analysis of the overlapping transcriptome (upregulated and downregulated) of the severe COVID-19 patients’ liver tissues with the disease signature of liver cirrhosis, liver fibrosis, and non-alcoholic fatty liver disease analyzed using Metascape. GDA score: Gene disease association score; F.C.: Fold change.