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. 2021 Jun 7;27(21):2850–2870. doi: 10.3748/wjg.v27.i21.2850

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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/

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Comparative analysis of the overlapping transcriptomes mapping to severe coronavirus disease 2019 liver tissue, hepatitis A, hepatitis B, and hepatitis C. A: Table representing the genes overlapping between the upregulated signature of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infected liver tissue samples and the signatures of hepatitis A, B, and C retrieved from DisGeNET; gene disease association score was retrieved from DisGeNET and fold change is calculated using AltAnalyze to represent the difference in expression in COVID-19 liver tissue samples vs non-COVID-19 liver samples; B: Top 20 pathways and functional clusters enriched in the commonly upregulated genes between SARS-CoV-2 infected liver tissues and hepatitis A, B, and C disease signatures analyzed using Metascape. GDA score: Gene disease association score; F.C.: Fold change.