Table 1.

Severity grading of immune checkpoint inhibitor-induced hepatotoxicity according to National Cancer Institute’s common terminology criteria for adverse events version 4.03

Grade	1 mild	2 moderate	3 severe	4 life-threatening
AST (× ULN)	> 1-3 ×	> 3-5 ×	> 5-20 ×	> 20 ×
ALT (× ULN)	> 1-3 ×	> 3-5 ×	> 5-20 ×	> 20 ×
ALP (× ULN)	> 1-2.5 ×	> 2.5-5 ×	> 5-20 ×	> 20 ×
GGT (× ULN)	> 1-2.5 ×	> 2.5-5 ×	> 5-20 ×	> 20 ×
Total bilirubin (× ULN)	> 1-1.5 ×	> 1.5-3 ×	> 3-10 ×	> 10 ×

AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; ULN: Upper limit of normal.