Set	Query	Results
#17	#16 NOT #17 AND [english]/lim	2,203
#18	#16 NOT #17	2,400
#17	(rat:ti OR rats:ti OR mouse:ti OR mice:ti OR swine:ti OR porcine:ti OR murine:ti OR sheep:ti OR lambs:ti OR pigs:ti OR piglets:ti OR rabbit:ti OR rabbits:ti OR cat:ti OR cats:ti OR dog:ti OR dogs:ti OR cattle:ti OR bovine:ti OR monkey:ti OR monkeys:ti OR trout:ti OR marmoset*:ti) AND ’animal experiment’/de	1,077,288
#16	#14 NOT #15	2,405
#15	‘animal experiment’/de NOT (‘human experiment’/de OR ‘human’/de)	2,272,297
#14	#5 AND #13	3,014
#13	#6 OR #7 OR #8 OR #9 OR #10 OR #11 OR #12	5,520,026
#12	((data NEAR/1 (synthes* OR extraction* OR abstraction*)):ti,ab) OR handsearch*:ti,ab OR ‘hand search’:ti,ab OR ’hand searches’:ti,ab OR ’hand searching’:ti,ab OR ‘mantel haenszel’:ti,ab OR peto:ti,ab OR ‘der simonian’:ti,ab OR dersimonian:ti,ab OR ‘fixed effect’:ti,ab OR ‘fixed effects’:ti,ab OR ‘latin square’:ti,ab OR ‘latin squares’:ti,ab OR ‘meta analysis’:ti,ab OR ‘meta analyses’:ti,ab OR ‘met analysis’:ti,ab OR ‘met analyses’:ti,ab OR metaanaly*:ti,ab OR metanaly*:ti,ab OR ‘meta regression’:ti,ab OR ‘meta regressions’:ti,ab OR metaregression*:ti,ab OR medline:ti,ab OR cochrane:ti,ab OR pubmed:ti,ab OR medlars:ti,ab OR embase:ti,ab OR cinahl:ti,ab OR cochrane:jt OR ‘evidence report’:jt OR ((comparative NEAR/3 (efficacy OR effectiveness)):ti,ab) OR ‘outcomes research’:ti,ab OR ‘relative effectiveness’:ti,ab OR (((indirect OR ‘indirect treatment’ OR ‘mixed treatment’) NEAR/3 comparison):ti,ab)	475,049
#11	((systematic* NEAR/3 (review* OR overview*)):ti,ab) OR ((methodologic* NEAR/3 (review* OR overview*)):ti,ab) OR ((quantitative NEAR/3 (review* OR overview* OR synthes*)):ti,ab) OR ((research NEAR/3 (integrati* OR overview*)):ti,ab) OR ((integrative NEAR/3 (review* OR overview*)):ti,ab) OR ((collaborative NEAR/3 (review* OR overview*)):ti,ab) OR ((pool* NEAR/3 analy*):ti,ab)	283,769
#10	‘meta analysis’/exp OR ’meta analysis (topic)’/exp OR 'systematic review’/exp OR 'systematic review (topic)’/exp OR ’biomedical technology assessment’/exp	415,886
#9	‘crossover procedure’/exp OR (((crossover OR ’cross over’) NEAR/10 (study OR studies OR design* OR method* OR procedure OR comparison)):ti,ab)	94,585
#8	((singl* OR doubl* OR trebl* OR tripl*) NEAR/10 (mask* OR blind* OR dumm*)):ti,ab	252,294
#7	‘clinical trial (topic)’/exp OR ’double blind procedure’/exp OR 'single blind procedure’/exp OR ’triple blind procedure’/exp	542,371
#6	‘clinical trial’/exp OR ’randomization’/exp OR randomized:ti,ab OR randomised:ti,ab OR placebo:ti,ab OR randomly:ti,ab OR trial:ti,ab OR groups:ti,ab	4,935,446
#5	#3 OR #4	10,181
#4	alipure:ti,ab,kw OR ‘alpha‐lipogamma’:ti,ab,kw OR ‘alphalipogamma’:ti,ab,kw OR ‘alpha‐lipon’:ti,ab,kw OR alphalipon:ti,ab,kw OR ‘alpha liponaure’:ti,ab,kw OR alphaliponaure:ti,ab,kw OR alphaliponsaure:ti,ab,kw OR ‘alpha liponsaure’:ti,ab,kw OR ‘alpha lippon’:ti,ab,kw OR alphalippon:ti,ab,kw OR ‘alpha vibolex’:ti,ab,kw OR alphavibolex:ti,ab,kw OR azulipont:ti,ab,kw OR berlition:ti,ab,kw OR berlithione:ti,ab,kw OR biletan:ti,ab,kw OR ‘biomo lipon’:ti,ab,kw OR biomolipon:ti,ab,kw OR ‘byodinoral r’:ti,ab,kw OR ‘coenzyme compositum’:ti,ab,kw OR ‘discus compositum’:ti,ab,kw OR duralipon:ti,ab,kw OR ‘espa lipon’:ti,ab,kw OR espalipon:ti,ab,kw OR fenint:ti,ab,kw OR ‘hepar compositium’:ti,ab,kw OR heparlipon:ti,ab,kw OR juthiac:ti,ab,kw OR ‘ledum compositum’:ti,ab,kw OR ‘lycopodium compositum’:ti,ab,kw OR liposan:ti,ab,kw OR ‘liponsaure‐ratiopharm’:ti,ab,kw OR liponsaureratiopharm:ti,ab,kw OR lipothion:ti,ab,kw OR mtwalphaliponsaure:ti,ab,kw OR neurium:ti,ab,kw OR octolipen:ti,ab,kw OR oktolipen:ti,ab,kw OR ‘pleomix alpha’:ti,ab,kw OR ‘quamtrax ala’:ti,ab,kw OR thioctacid:ti,ab,kw OR thioctacide:ti,ab,kw OR thioctan:ti,ab,kw OR thioctsan:ti,ab,kw OR thiogamma:ti,ab,kw OR thiotacid:ti,ab,kw OR tromlipon:ti,ab,kw OR tioctacid:ti,ab,kw OR tioctan:ti,ab,kw OR tioctidasi:ti,ab,kw OR ‘ubichinon compositum’:ti,ab,kw OR ‘verla lipon’:ti,ab,kw OR verlalipon:ti,ab,kw OR zeel:ti,ab	141
#3	#1 OR #2	10,112
#2	((‘1 2 dithiolan 3 pentanic’ OR 12dithiolan3pentanic OR ’1 2 dithiolane 3 pentanoic’ OR ’12dithiolane3pentanoic’ OR ’1 2 dithiolane 3 valeric’ OR ’12dithiolane3valeric’ OR ’5 dithiolan 3 yl valeric’ OR ’5dithiolan3ylvaleric’ OR ’5 1 2 dithiolan 3 yl valeric’ OR 512ditiolan3ylvaleric OR 68thioctic OR ’6 8thioctic acid’ OR αlipoic OR alipoic OR lipoic OR liponic OR thioctic OR tioctic) NEAR/3 (acidOR acids)):ti,ab,kw	6,833
#1	‘thioctic acid’/exp OR ’1077 28 7’:ti,ab,kw OR 1077287:ti,ab,kw	9,259