Figure 3. Response of GOPC-ROS1 Fusion Agminated Spitz Nevi Following Crizotinib Treatment.

A, Before treatment, multiple coalescent erythematous and pigmented papules of recurrent Spitz nevi were seen involving the right upper and lower eyelids, including a medial canthus nevus adjacent to the right upper punctum pressing on the globe, and lesions affecting the right tragus, crus of the helix, and just superior to the right ear. B, After 20 weeks of crizotinib treatment, dramatic reduction and flattening were demonstrated of all periorbital and auricular lesions to faint pigmented macules.