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. 2021 Jun 3;184(15):3962–3980.e17. doi: 10.1016/j.cell.2021.05.046

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© 2021 The Authors

Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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HLA-I peptides dynamics in SARS-CoV-2-infected cells

(A and B) Dynamics of TMT-labeled HLA-I peptides 3, 6, 12, 18, and 24 hpi in A549 (A) and HEK293T cells (B). TMT intensity values of peptides detected in two independent experiments (3, 6, and 24 hpi and 12, 18, and 24 hpi) were normalized to the respective abundance at 24 h present in both experiments. Dashed lines indicate detection in the 3|6|24-h plex only.

(C) Dynamics of SARS-CoV-2 protein expression according to whole-proteome analysis.

(D) Venn diagram showing SARS-CoV-2 proteins according to their earliest expression time and the source proteins for HLA-I-presented peptides in A549 and HEK293T cells. The hypergeometric p value represents the enrichment of early-expressed proteins (3 hpi) in the group of proteins presented on HLA-I.

(E) CD8+ responses to early/late-expressed SARS-CoV-2 proteins in convalescent COVID-19 individuals according to a recent study. The box shows the quartiles, the bar indicates median, and the whiskers show the distribution (see Table S3 in Tarke et al., 2020).