Table 2. Screening of the Mitsunobu Reaction on a 50 g Scale (Scheme 2).

entry	solvent	volume (mL)	temperature (°C)	TPPO-H2DIAD (dry) by filtration (g)	product isolation	yield (%)
1	THF	250	0–5	0	column	71
2	toluene	500	25–30	0	column	70
3	toluene	500	–5–0	5.5	column	70
4	toluene	200	25–30	10	column	70
5	toluene	200	–5–0	75	IPA (125 mL)	68