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. 2021 May 20;12:662003. doi: 10.3389/fphar.2021.662003

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Copyright © 2021 Zhao, Ma, Xu, Yao, Zhang, Xue, Ren, Chang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histological and Ultrastructural Changes Associated with JDTL Granules Treatment. H&E staining of the hippocampal CA3 area [(A), ×40]. Cells were structurally intact and with clear cytoplasm in the control group. In the model group, degeneration and necrosis occurred with reduced cells, scattered arrangement (arrow), and condensed and deep stained nucleus. Minor damage was observed in JDTL granules and fluoxetine groups. Ultrastructural characteristics of the nucleus [(B), ×20,000] and mitochondria [(C), ×40,000] in the hippocampal area. The control group neurons were with intact shape and uniform chromatin in the nucleus. Furthermore, the mitochondria were apparent and remained intact. The model group’s nucleus showed nuclear pyknosis, and the mitochondria deform, swell, and vacuolization (arrow). The treatment of JDTL granules and fluoxetine reduced the damage.