Table 5.

PK parameters of C₆CP and paclitaxel in plasma and tumor after administering polymeric micelle in A2780/CisR tumor bearing mice. Reprinted with permission from [188] Copyright 2018, Elsevier.

	Parametersa	C6CPb, 20 mg/kg			paclitaxel, 20 mg/kg
		paclitaxel/C6CP polymeric micelle	C6CP polymeric micelle	Parameter ratioc	paclitaxel/C6CP polymeric micelle	paclitaxel polymeric micelle	Parameter ratiod
Plasma	t1/2, α (h)	7.67	6.20	1.24	5.12	3.67	1.40
	Cmax (μg/mL)	9.40	4.71	1.99	6.51	4.62	1.41
	AUClast (h*μg/mL)	34.80	30.00	1.16	18.41	9.78	1.88
	Clobs (mL/h/kg)	527.40	541.00	0.97	984.06	1434.66	0.69
	Vdobs (mL/kg)	5077.11	7963.56	0.64	10112.89	7689.6	1.32
Tumor	AUClast (h*μg/g)	110.92	38.68	2.87	111.14	87.28	1.27
	Cmax (μg/g)	9.86	4.34	2.27	8.34	5.38	1.55
	Tmax (h)	1	1		1	1

^at_1/2, _α, half-life at the biodistribution phase; C_max, maximum plasma concentration; AUC_last, area under the curve from time 0–15 h; Cl_obs, observed total body clearance; Vd_obs, total volume of distribution observed; T_max, time of maximum concentration

^bHydrophobic derivatives of cisplatin with aliphatic chains of 6 carbon atoms at the axial positions

^cpaclitaxel/C₆CP polymeric micelle: C₆CP polymeric micelle

^dpaclitaxel/C₆CP polymeric micelle: paclitaxel polymeric micelle