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. 2021 Jun 2;19:236. doi: 10.1186/s12967-021-02886-3

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Images obtained in a 49-year-old woman with invasive ductal carcinoma (estrogen receptor+/progesterone receptor+/human epidermal growth factor receptor 2-/Ki-67 > 20%) who was categorized in the non-pathologic complete response group. Shown from left to right are contrast-enhanced MRI images, diffusion-weighted (DW) MRI images (b = 1500 s/mm²), and color-coded quantitative DW MRI maps (overlaid on original DW images). Serial diffusion-related measures showed no obvious increase with treatment. For example, ADC_200,1000 values were 0.86, 0.89 and 0.80 × 10^–3 mm²/s, respectively, at pre-, mid-, and post-treatment