Table 4.
Univariate and multivariate analyses of variables associated with pCR
| Variable | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Odds ratio* | P value | Odds ratio* | P value | |
| Pre-treatment | ||||
| Age | 0.986 (0.953, 1.021) | 0.429 | – | – |
| Menopause (post- vs. pre-menopausal) | 2.083 (0.895, 4.850) | 0.089 | – | – |
| Histologic type (IDC vs. Non-IDC) | 1.770 (0.177, 17.665) | 0.626 | – | – |
| ER (negative vs. positive) | 11.388 (4.367, 29.698) | < 0.001 | 11.433 (3.363, 38.874) | < 0.001 |
| PR (negative vs. positive) | 2.388 (0.970, 5.881) | 0.058 | – | – |
| HER2 (positive vs. negative) | 5.104 (2.131, 12.227) | < 0.001 | 5.469 (1.631, 18.339) | 0.006 |
| Ki-67 (≥ 20% vs. < 20%) | 14.087 (1.795, 110.566) | 0.012 | 3.852 (0.299, 49.574) | 0.301 |
| Mid-treatment | ||||
| ΔADC200,1000 (> 0.33 vs. ≤ 0.33 × 10–3 mm2/s) | 13.481 (5.066, 35.877) | < 0.001 | 9.074 (2.847, 28.917) | < 0.001 |
| ΔSize (≤ − 26.6 vs. > − 26.6 mm) | 5.098 (2.070, 12.553) | < 0.001 | 2.351 (0.697, 7.931) | 0.168 |
| ΔRER (≤ − 87.5% vs. > -87.5%) | 4.202 (1.748, 10.100) | 0.001 | 1.231 (0.339, 4.467) | 0.752 |
*Data in parentheses are 95% confidence intervals
For binary categorical variables, the latter category in the parentheses was used as the reference
IDC: invasive ductal carcinoma; pCR: pathologic complete response; ER: estrogen receptor; PR: progesterone receptor; HER2: human epidermal growth factor receptor 2; ADC: apparent diffusion coefficient; RER: relative enhancement ratio