Table 2.
Prevalence of ILD Family History Stratified by ILD Subtype
| Demographics | All Patients (N = 1,262) | IPF ILD (n = 534) | Non-IPF ILD (n = 728) |
|||
|---|---|---|---|---|---|---|
| Combined (n = 728) | CTD-Associated ILD (n = 234) | CHP (n = 197) | uILD (n = 297) | |||
| Family history of ILD | 224 (17.7) | 134 (25.1) | 90 (12.4) | 18 (7.7) | 27 (13.7) | 45 (15.2) |
| Affected first-degree relatives in FPF cohorts | ||||||
| 1 | 150 (67) | 81 (60.4) | 69 (76.7) | 16 (88.8) | 22 (81.5) | 31 (68.9) |
| 2 | 48 (21.4) | 34 (25.4) | 14 (15.6) | 0 | 4 (14.8) | 10 (22.2) |
| ≥ 3 | 18 (8) | 13 (9.7) | 5 (5.6) | 1 (5.6) | 1 (3.7) | 3 (6.7) |
| Affected second-degree relatives only | 8 (3.6) | 6 (4.5) | 2 (2.2) | 1 (5.6) | 0 | 1 (2.2) |
Data are presented as No. (%). CHP = chronic hypersensitivity pneumonitis; CTD = connective tissue disease; FPF = familial pulmonary fibrosis; ILD = interstitial lung disease; IPF = idiopathic pulmonary fibrosis; uILD = unclassifiable ILD.