Table 3.
Comparison of Baseline Characteristics Between Familial and Sporadic ILD Subtypes
| Demographics | Familial IPF (n = 134) | Sporadic IPF (n =400) | Familial CTD-Associated ILD (n = 18) | Sporadic CTD-Associated ILD (n = 216) | Familial CHP (n = 27) | Sporadic CHP (n = 170) | Familial uILD (n = 45) | Sporadic uILD (n = 252) |
|---|---|---|---|---|---|---|---|---|
| Age, y | 64.6 ± 10.2a | 69.4 ± 9.7 | 67.5 ± 8.6a | 56.1 ± 14.7 | 64.9 ± 10.1 | 66.5 ± 10.8 | 63.2 ± 10.3 | 66.3 ± 12.1 |
| Male sex | 91 (67.9)a | 306 (76.5) | 5 (27.8) | 70 (32.4) | 11 (40.7) | 95 (55.9) | 22 (48.9) | 131 (52) |
| White race | 112 (83.6) | 348 (87) | 15 (83.3)a | 128 (59.3) | 21 (77.8) | 146 (85.9) | 36 (80.0) | 196 (77.8) |
| Ever smoker | 76 (56.7)a | 266 (67.3) | 12 (66.7)a | 90 (41.7) | 12 (44.4) | 77 (45.3) | 24 (53.3) | 137 (54.4) |
| FVC, % predicted | 68.9 ± 17.7 | 69.5 ± 18.7 | 80.7 ± 17.9a | 67.9 ± 20.2 | 61.9 ± 19.2 | 64.2 ± 20.4 | 71.3 ± 18.9 | 68.2 ± 21.2 |
| Diffusion capacity, % predicted | 48.5 ± 17.4 | 46 ± 18.6 | 52.7 ± 18.2 | 45.3 ± 17.9 | 46.5 ± 17.1 | 46.3 ± 19.1 | 50.9 ± 15.1 | 46.7 ± 19 |
Data are presented as No. (%) or mean ± SD. CHP = chronic hypersensitivity pneumonitis; CTD = connective tissue disease; ILD = interstitial lung disease; IPF = idiopathic pulmonary fibrosis; uILD = unclassifiable ILD.
a
P < .05 compared with the sporadic form of the disease.