Table 4.
Risk of Death or Lung Transplantation for Patients With Familial ILD When Compared With Their Sporadic Counterparts
| ILD Subtype | Unadjusted |
Adjusteda |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | |
| Familial IPF | 1.41 | 1.09-1.82 | .01 | 1.80 | 1.37-2.37 | < .001 |
| Familial non-IPF | 1.79 | 1.26-2.54 | .001 | 2.08 | 1.46-2.96 | < .001 |
| Familial CTDb | 2.63 | 1.11-6.23 | ... | ... | ... | ... |
| Familial CHPb | 1.84 | 1.00-3.40 | ... | ... | ... | ... |
| Familial uILDb | 1.19 | 0.73-1.96 | ... | ... | ... | ... |
CHP = chronic hypersensitivity pneumonitis; CTD = connective tissue disease; ILD = interstitial lung disease; IPF = idiopathic pulmonary fibrosis; uILD = unclassifiable ILD.
a
Adjusted for center as a random effect and race and Gender, Age, Physiology stage as fixed effects.
b
Proportional hazards assumption violated graphically so nominal, unadjusted effect estimates are reported.