Table 1.
Baseline Characteristics of Study Patients Who Were Ventilated Mechanically on Day 1 According to Renal Replacement Therapy Intensity Randomized Groups
| Characteristic | Less-Intensive Strategya | More-Intensive Strategyb | P Valuec |
|---|---|---|---|
| Age, mean ± SD, y | 59.3 ± 15.3 | 59.3 ± 15.3 | .95 |
| Male, % | 68.5 | 72.3 | .21 |
| Black, % | 15.5 | 16.4 | .71 |
| Mean weight, mean ± SD, kg | 84.2 ± 19 | 83.6 ± 19.5 | .67 |
| Patients alive at 14 days, n/No. (%) | 288/451 (63.8) | 293/456 (64.2) | .75 |
| Hypertension, % | 2.6 | 2.8 | .20 |
| Diabetes mellitus, % | 24.6 | 30 | .14 |
| Malignancy, % | 13.5 | 18.4 | .11 |
| Ischemic heart disease, % | 21.3 | 21.7 | .73 |
| Congestive heart failure, % | 21 | 20.6 | .80 |
| Primary treating service, n/No. (%) | .65 | ||
| Medical | 198/451 (43.9) | 214/456 (46.9) | |
| Surgical | 201/451 (44.5) | 191/456 (41.8) | |
| Other | 52/451 (11.5) | 51/456 (11.1) | |
| Mode of renal replacement therapy on day 1, n/No. (%) | .14 | ||
| Continuous venovenous hemodiafiltration | 314/388 (80.9) | 313/395 (79.2) | |
| Intermittent hemodialysis | 53/388 (13.6) | 61/395 (15.4) | |
| Sustained low efficiency dialysis | 15/388 (3.9) | 20/395 (5.0) | |
| Isolated ultrafiltration | 6/388 (1.5) | 1/395 (0.2) | |
| Chronic hypoxemia, % | 9 | 10.9 | .39 |
| Cardiovascular Sequential Organ Failure Assessment score (range) | 3 (0 to 4) | 3 (0 to 4) | 1 |
| Apache II score, mean ± SD | 27.5 ± 7.1 | 28.1 ± 6.7 | .2 |
| Serum calcium, mean ± SD, (mg/dL) | 7.5 ± 1.1 | 7.5 ± 1 | .71 |
| Serum creatinine, mean ± SD, mg/dL | 3.6 ± 1.5 | 3.6 ± 1.5 | .72 |
| Serum phosphate, mean ± SD, mg/dL | 5.4 ± 2.2 | 5.4 ± 2.1 | 1 |
| Serum albumin, mean ± SD, g/dL | 2.3 ± 0.3 | 2.3 ± 0.4 | 1 |
a
No. of participants with events = 154/451.
b
No. of participants with events = 113/456.
c
P value for difference; significant testing was done by χ2 for categoric variables and by t- test for continuous variables.