Table 2.
Cox-Proportional Hazard Modelsa
| Variable | Participants With Events, n/No. | HR (95% CI) |
|
|---|---|---|---|
| Unadjusted Model | Multivariable-Adjusted Modelb | ||
| Overall study sample | 267/907 | 0.67 (0.53-0.85) | 0.67 (0.52-0.88) |
| Subgroup analyses | |||
| Sepsis | 137/495 | 0.62 (0.43-0.86) | 0.60 (0.42-0.85) |
| Baseline serum phosphate | |||
| Tertile 1 (1.2-4.3 mg/dL) | 87/242 | 0.56 (0.36-0.87; P < .05) | 0.57 (0.37-0.88; P < .05) |
| Tertile 2 (4.4-6.3 mg/dL) | 83/257 | 0.76 (0.49-1.1; P = .21) | 0.78 (0.5-1.2; P = .28) |
| Tertile 3 (6.4-15.3 mg/dL) | 56/244 | 0.71 (0.42-1.2; P = .21) | 0.65 (0.37-1.1; P = .13) |
a
With endpoint of first extubation from mechanical ventilation according to renal replacement therapy intensity randomized groups with adjustment by prespecified covariates along with subgroup analysis; the referent group is the less-intensive arm.
b
Adjusted for baseline age, sex, race (black vs non-black), weight, fluid balance, ischemic heart disease, congestive heart failure, chronic hypoxemic condition, hypertension, diabetes mellitus, and the cardiovascular component of the sequential organ failure assessment score (0, 1, 2, 3, or 4).