Table 3.
Unadjusted and Adjusted Transplant-Free Survival by Clinical Predictors
| Clinical Predictor | Unadjusted Hazard Ratioa | P Value | Model 1 | P Value | Model 2 | P Value | Model 3 | P Value |
|---|---|---|---|---|---|---|---|---|
| Age at diagnosis | 1.02 (0.98 to 1.06) | .38 | 1.06 (0.99 to 1.13) | .08 | 1.03 (0.98 to 1.09) | .18 | 1.02 (0.96 to 1.11) | .42 |
| Sexb | 0.73 (0.36 to 1.48) | .39 | … | … | … | … | … | … |
| BMI, kg/m2 | 0.95 (0.88 to 1.02) | .16 | … | … | … | … | … | … |
| Smoking pack years | 1.01 (0.99 to 1.02) | .06 | … | … | … | … | … | … |
| 6MWD, m | 0.99 (0.99 to 0.99)c | .048c | … | … | … | … | … | … |
| Borg dyspnea | 1.09 (0.93 to 1.28) | .29 | … | … | … | … | … | … |
| Oxygen use | 2.90 (1.12 to 7.51)c | .028c | … | … | 1.34 (0.45 to 4.02) | .59 | … | … |
| FEV1% predicted | 1.00 (0.98 to 1.02) | .65 | 0.99 (0.98 to 1.01) | .84 | … | … | … | … |
| FVC% predicted | 1.00 (0.99 to 1.02) | .83 | … | … | … | … | … | … |
| FEV1/FVC% | 1.01 (0.99 to 1.04) | .33 | … | … | … | … | … | … |
| RV% predicted | 0.99 (0.99 to 1.00) | .19 | … | … | … | … | … | … |
| Dlco% predicted | 0.96 (0.94 to 0.98)c | < .001c | 0.96 (0.94 to 0.99)c | .003c | 0.96 (0.94 to 0.99)c | .006c | 0.96 (0.94 to 0.99)c | .03a |
| NT-proBNP,d pg/dL | 2.51 (1.32 to 4.79)c | .005c | … | … | … | … | 1.16 (0.51 to 2.63) | .72 |
| Creatinine, mg/dL | 1.37 (0.46 to 4.09) | .58 | … | … | … | … | … | … |
| mPAP, mm Hg | 1.02 (1.00 to 1.06)c | .03c | … | … | … | … | … | … |
| PVR, Wood units | 1.07 (1.01 to 1.14)c | .02c | 1.04 (0.96 to 1.12) | .12 | 1.04 (0.96 to 1.12) | .36 | 1.04 (0.95 to 1.13) | .42 |
| Cardiac output, L/min | 0.76 (0.58 to 0.99)c | .045c | … | … | … | … | … | … |
| Pulmonary capillary wedge pressure, mm Hg | 0.95 (0.89 to 1.02) | .15 | … | … | … | … | … | … |
| PH medication use | 1.85 (0.84 to 4.09) | .13 | … | … | … | … | … | … |
Model 1 (N = 53) included age at diagnosis, FEV1% predicted, Dlco% predicted, and PVR as covariates. Model 2 (N = 53) included age at diagnosis, oxygen use, Dlco% predicted, and PVR. Model 3 (N = 39) included age at diagnosis, Dlco% predicted, NT-proBNP, and PVR. See Table 1 legend for expansion of abbreviations.
a
Hazard ratios are reported per 1 unit increase in clinical predictor.
b
Sex hazard ratio is for female vs male.
c
Denotes statistical significance P < .05.
d
NT-proBNP was log10-transformed for normality; NT-proBNP is per 10-fold increase in pg/mL.