Table 3.
Exploratory Cox Proportional Hazard Models for ACEI/ARB or AA Exposure in Veterans Including Adjustment for Potassium Level or Disease Severity
| Variable | Full Cohort |
Propensity-Matched Cohort |
||
|---|---|---|---|---|
| HR (95% CI) | P Value | HR (95% CI) | P Value | |
| ACEI/ARB | ||||
| Full adjustmenta | 0.81 (0.78-0.84) | < .001 | 0.82 (0.78-0.86) | < .001 |
| Full adjustmenta with further adjustment for potassium | 0.80 (0.77-0.83)b | < .001 | 0.81 (0.77-0.85)c | < .001 |
| Full adjustmenta with further adjustment for disease severityd | 0.72 (0.67-0.78)e | < .001 | 0.77 (0.70-0.85)f | < .001 |
| AA | ||||
| Full adjustmenta | 1.24 (1.18-1.30) | < .001 | 1.07 (1.00-1.14) | .05 |
| Full adjustmenta with further adjustment for potassium | 1.23 (1.17-1.30)b | < .001 | 1.08 (1.01-1.15)g | .03 |
| Full adjustmenta with further adjustment for disease severityd | 1.05 (0.96-1.14)e | .28 | 1.04 (0.93-1.16)h | .48 |
Fully adjusted models for entire cohort and propensity-matched cohort (from Table 2) are included for reference. AA = aldosterone antagonist; ACEI = angiotensin converting enzyme inhibitor; ARB = angiotensin receptor blocker; HR = hazard ratio.
a
Age, sex, race or ethnicity, BMI, income, tobacco use, alcohol use, and marital status.
b
n = 21,586.
c
n = 13,211.
d
Adjustment for disease severity also accounts for B-type natriuretic peptide level and inpatient admission.
e
n = 5,823.
f
n = 3,302.
g
n = 7,349.
h
n = 2,676.