Table 1.
Characteristics of mouse β-cell SASP signature proteins
| Protein | Secreted? (yes/no) | Subcellular localization | Extracellular localization |
|---|---|---|---|
| Upregulated | |||
| NAMPT | Yes | Nuclear speckles, cell junctions | Blood |
| IL27 | Yes | Blood | |
| EBI3 | Yes | Blood | |
| TSLP | Yes | Golgi apparatus, vesicles | Blood |
| IL22 | Yes | Blood | |
| CD40LG | Yes | Plasma membrane | Blood |
| ANXA1 | Yes | Plasma membrane, cytosol, nucleoplasm | Blood |
| CXCL3 | Yes | Blood | |
| CXCL2 | Yes | Blood | |
| TGFBR3 | Yes | Cytosol | Blood |
| MBL2 | Yes | Blood | |
| GDF15 | Yes | Golgi apparatus | Blood |
| JAM3 | Yes | Plasma membrane, Golgi apparatus | Blood |
| CSH1 | Yes | Blood | |
| CSH2 | Yes | Blood | |
| AMH | Yes | Vesicles, aggresome | Blood |
| EFEMP1 | Yes | Mitochondria | ECM |
| LAMA1 | Yes | ECM | |
| LAMB1 | Yes | ECM | |
| LAMC1 | Yes | Plasma membrane, endoplasmic reticulum | ECM |
| CLEC11A | Yes | Centrosome | Local |
| RSPO2 | Yes | Local | |
| FGF6 | Yes | Local | |
| KLK6 | Yes | Nucleoplasm, nuclear membrane, cytokinetic bridge | Local |
| FGF7 | Yes | Nucleoplasm, nucleoli | Local |
| FGF16 | Yes | Local | |
| SFN | Yes | Cytosol, nucleoli | Local |
| DHH | Yes | Male reproductive system | |
| PDCD1LG2 | Yes | Cytosol | |
| TACSTD2 | No | Plasma membrane, nucleoli, vesicles | |
| MSLN | No | Plasma membrane, vesicles, nucleoplasm | |
| LGALS4 | No | Plasma membrane | |
| DDR2 | No | Plasma membrane, actin filaments | |
| HHLA2 | No | Plasma membrane | |
| EDAR | No | Plasma membrane | |
| NCAM1 | No | Plasma membrane, cytosol | |
| FLRT1 | No | Plasma membrane | |
| LMAN2 | No | Plasma membrane | |
| SEZ6L2 | No | Plasma membrane | |
| HINT1 | No | Plasma membrane, nucleoplasm, cytosol | |
| NCK1 | No | Plasma membrane, cytosol | |
| RPSA | No | Plasma membrane, cytosol | |
| NUDCD3 | No | Plasma membrane, cytosol, nucleoplasm | |
| CAMK2B | No | Plasma membrane, cell junctions, cytosol | |
| MAP2K1 | No | Plasma membrane, cytosol | |
| CRK | No | Plasma membrane | |
| YES1 | No | Plasma membrane, cytosol | |
| CAMK2D | No | Plasma membrane, cell junctions, cytosol | |
| KIR2DL4 | No | Plasma membrane | |
| PAFAH1B2 | No | Cytosol, nucleoli, plasma membrane | |
| NSFL1C | No | Nucleoplasm, cytosol, plasma membrane | |
| EIF5 | No | Plasma membrane, cytosol | |
| CTSC | No | Vesicles | |
| ULBP3 | No | Vesicles, centriolar satellite | |
| CASP10 | No | Golgi apparatus, vesicles | |
| LRRK2 | No | Nucleoplasm, vesicles | |
| AKT2 | No | Nucleoplasm, vesicles, cytosol | |
| PPA1 | No | Vesicles | |
| HSPA1A | No | Nucleoplasm, vesicles, cytosol | |
| COMMD7 | No | Vesicles | |
| VTA1 | No | Nucleoplasm, vesicles, cytosol | |
| SKP1 | No | Nucleoplasm, cytosol | |
| LGALS2 | No | Mitochondria, nucleoplasm | |
| RBM39 | No | Nucleoplasm, nuclear speckles, microtubules, centriolar satellite | |
| HDGFRP2 | No | Nucleoplasm, mitochondria | |
| UBE2L3 | No | Nucleoplasm, cytosol | |
| ARID3A | No | Nucleoplasm, cytosol | |
| RPS6KA5 | No | Nucleoplasm | |
| GRB2 | No | Nucleoplasm | |
| KPNB1 | No | Nuclear membrane, nucleoplasm, cytosol | |
| LTA4H | No | Nucleoplasm, cytosol | |
| FGF12 | No | Nucleoplasm, cytosol | |
| UBE2N | No | Nucleoplasm, nucleoli fibrillar center | |
| AKR1A1 | No | Cytosol, nucleoplasm | |
| UCHL1 | No | Cytoplasm, nucleoplasm | |
| ING1 | No | Nucleoplasm, cytosol | |
| YWHAB | No | Cytosol, nucleoplasm, nucleoli | |
| YWHAE | No | Cytosol, nucleoplasm, nucleoli | |
| YWHAG | No | Cytosol, nucleoplasm, nucleoli | |
| YWHAQ | No | Cytosol, nucleoplasm, nucleoli | |
| YWHAZ | No | Cytosol, nucleoplasm, nucleoli | |
| NAGK | No | Cytosol, nucleoplasm | |
| DUSP3 | No | Nucleoplasm, cytosol | |
| STAT3 | No | Nucleoplasm, cytosol | |
| HPGD | No | Nucleoplasm, cytosol | |
| PPID | No | Nucleoli, cytosol, nucleoplasm | |
| EIF5A | No | Nucleoplasm, cytosol | |
| PTPN6 | No | Nucleoplasm, nucleoli | |
| PGM1 | No | Cytosol | |
| AIP | No | Cytosol | |
| TPM4 | No | Actin filaments, cytosol | |
| PRKCI | No | Cytosol, microtubules, cytokinetic bridge | |
| YWHAH | No | Cytosol, nucleoli | |
| TAGLN2 | No | Cytosol, actin filaments | |
| GSTP1 | No | Mitochondria, cytosol | |
| UFC1 | No | Nuclear speckles, cytosol | |
| MAPK14 | No | Nuclear speckles, cytosol | |
| SHC1 | No | Cytosol | |
| HSP90AA1 | No | Cytosol | |
| HSP90AB1 | No | Cytosol | |
| IMPDH1 | No | Cytosol, rods, and rings | |
| XPNPEP1 | No | Cytosol | |
| SNX4 | No | ||
| PDXP | No | ||
| TXNDC12 | No | ||
| UFM1 | No | ||
| DCTN2 | No | Centrosome | |
| PRDX1 | No | Mitochondria | |
| PGK1 | No | ||
| Downregulated | |||
| TNFRSF6B | Yes | Blood | |
| SPP1 | Yes | Golgi apparatus | Blood |
| TNFSF14 | Yes | Plasma membrane | Blood |
| IL36B | Yes | Blood | |
| EPO | Yes | Blood | |
| ISG15 | Yes | Blood | |
| IL36A | Yes | Blood | |
| IFNA7 | Yes | Blood | |
| MMP10 | Yes | ECM | |
| MMP1 | Yes | Vesicles | ECM |
| RSPO4 | Yes | Local | |
| TFF1 | Yes | Digestive system | |
| IFNAR1 | No | Plasma membrane | |
| IFNGR2 | No | Plasma membrane | |
| ITGAV | No | Plasma membrane, focal adhesion sites, cytosol | |
| ITGB5 | No | Plasma membrane, mitochondria | |
| PIANP | No | Plasma membrane, nucleoplasm | |
| PDGFRA | No | Plasma membrane, nucleoplasm, cell junctions | |
| FCGR2A | No | Plasma membrane, Golgi apparatus | |
| CD300C | No | Plasma membrane, Golgi apparatus, vesicles, mitochondria | |
| EFNA3 | No | Plasma membrane | |
| SCARB2 | No | Plasma membrane, cytosol | |
| GAS1 | No | Nuclear speckles | |
| GNS | No | ||
| ASGR1 | No | Vesicles, cell junctions | |
| PRKAA1 | No | Nuclear speckles | |
| HIBADH | No |