Table 3.
Characteristics of human β-cell SASP signature proteins
| Protein | Secreted? (yes/no) | Subcellular localization | Extracellular localization |
|---|---|---|---|
| Upregulated | |||
| FCGR2B | No | ||
| FRZB | Yes | Locally | |
| CAMK1D | No | Cytosol, nucleoplasm | |
| TNFSF8 | No | ||
| CCL3L1 | Yes | Blood | |
| CD80 | No | ||
| CD22 | No | ||
| AFM | Yes | Blood | |
| CLU | Yes | Blood | |
| FGF8 | Yes | Locally | |
| TNFSF18 | No | ||
| PCSK7 | No | ||
| CFD | Yes | Blood | |
| SMAD3 | No | Cytosol, nucleoplasm | |
| RB1 | No | Nucleoplasm | |
| BMPR2 | No | ||
| CD200 | No | ||
| CKM | No | ||
| ANGPTL3 | Yes | Blood | |
| CCL1 | Yes | Blood | |
| GSK3A | No | Cytosol | |
| GSK3B | No | Nucleoplasm | |
| JUN | No | Nucleoplasm | |
| CPE | No | Centrosome, nucleoplasm, vesicles | |
| WIF1 | Yes | ECM | |
| TNFRSF13B | No | ||
| ENTPD1 | No | Microtubules | |
| ICOS | No | Actin filaments, plasma membrane | |
| GPC3 | No | Plasma membrane | |
| VCAM1 | No | Cell junctions | |
| ACVRL1 | No | ||
| TPM2 | No | ||
| PLA2G7 | Yes | Blood | |
| ICAM3 | No | Mitochondria, nuclear membrane, nucleoplasm | |
| ASAH2 | No | Focal adhesion sites | |
| IL10RB | No | Cytosol | |
| BIRC5 | No | Cytokinetic bridge | |
| NOTCH1 | No | Nucleoplasm | |
| IBSP | Yes | Locally | |
| SELE | No | ||
| IL37 | Yes | Nucleoplasm, vesicles | Blood |
| BCL2L1 | No | Mitochondria | |
| CST7 | Yes | Blood | |
| REN | Yes | Blood | |
| LTBR | No | Golgi apparatus | |
| SFRP1 | Yes | Cytosol, nucleoli | Locally |
| EDA | No | Lipid droplets, vesicles | |
| FST | Yes | Blood | |
| CD109 | No | Plasma membrane | |
| OSM | Yes | Blood | |
| C8A | Yes | Blood | |
| C8B | Yes | Blood | |
| C8G | Yes | Blood | |
| DSG1 | No | ||
| PLG | Yes | Blood | |
| PRLR | No | ||
| Downregulated | |||
| TPSB2 | Yes | Blood | |
| CAPG | No | Nucleoplasm | |
| DDR1 | No | Cell junctions, nucleoplasm | |
| PDXK | No | Nucleoplasm | |
| NTF3 | Yes | Vesicles | Locally |
| MPO | No | Nucleoplasm, vesicles | |
| PGLYRP1 | Yes | Blood | |
| LYN | No | Golgi apparatus, plasma membrane, vesicles | |
| THPO | Yes | Blood | |
| NUDCD3 | No | Cytosol, plasma membrane, nucleoplasm | |
| RSPO3 | Yes | Blood | |
| CTSH | No | Cytoplasmic bodies, cytosol, vesicles | |
| FGF6 | Yes | Locally | |
| MAPK12 | No | Cytosol, nuclear speckles | |
| PLA2G1B | Yes | Digestive system | |
| PGD | No | Cytosol, intermediate filaments | |
| IL20 | Yes | Blood | |
| AZU1 | Yes | Vesicles | Blood |
| VIP | Yes | Endoplasmic reticulum | Blood |
| UNC5D | No | ||
| NR3C1 | No | Cytosol, mitochondria, nucleoplasm | |
| HBEGF | Yes | Blood | |
| SGTA | No | Nucleoplasm | |
| FGF8 | Yes | Locally | |
| MSLN | No | Nucleoplasm, vesicles | |
| IFNL1 | Yes | Blood | |
| LTA | Yes | Blood | |
| LTB | No | Centrosome | |
| SIGLEC6 | No | ||
| S100A4 | No | Plasma membrane | |
| ANGPT4 | Yes | Blood | |
| CGA | Yes | Blood | |
| TSHB | Yes | Blood | |
| ADAMTS1 | Yes | Plasma membrane | ECM |
| C3 | Yes | Blood | |
| ALB | Yes | Endoplasmic reticulum, Golgi apparatus | Blood |
| ARID3A | No | Cytosol, nucleoplasm | |
| IL20RA | No | Cytosol | |
| IL4R | Yes | Centriolar satellite, plasma membrane, nucleoplasm | Blood |
| EPHA3 | No | Actin filaments, cytosol, nuclear membrane, nucleoplasm, plasma membrane |
|
| ADGRE2 | No | Cytosol, vesicles | |
| LGALS2 | No | Mitochondria, nucleoplasm | |
| PLXNB2 | No | ||
| CCL8 | Yes | Blood | |
| ADCYAP1 | Yes | Locally | |
| YWHAQ | No | Cytosol, nucleoli, nucleoplasm | |
| CSF2 | Yes | Vesicles | Blood |
| MAPK9 | No | ||
| LIFR | No | Golgi apparatus, nuclear speckles | |
| IL23R | No | ||
| DDC | No | Actin filaments | |
| HSPB1 | No | Cytosol, plasma membrane | |
| FCGR2A | No | Golgi apparatus, plasma membrane |