Mitochondrial coupling and oxidative function relationships to muscle performance and physical function. Pearson bivariate correlation plots depicting interrelationships among mitochondrial respiration states (complex 1 respiration [state 3-C1], maximal oxidative phosphorylation [Oxphos] [state 3-C1 +C2], ETS coupling efficiency [ETS capacity/E), knee extensor muscle performance (endurance/work over the fatigue task, force production/torque, power production), and physical function (PPT score). All depicted correlations are significant (P < 0.05). Knee extensor power was assessed as in Fig. 2 (120°/s isokinetic speed), with knee extensor torque measured in ft-lb (30°/s).