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. 2021 Jun 3;22:298. doi: 10.1186/s12859-021-04211-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Volcano plots and heatmap of dysregulated small ncRNAs and impacted pathways. (A) This figure shows a volcano plot generated by RNAdetector in its final report with the up-regulated (red) and down-regulated (green) small ncRNAs identified after the comparison between CRC samples vs adjacent normal tissue samples. A volcano plot combines the results of a statistical test with the magnitude of the change enabling quick visual identification of those genes that display large-magnitude changes that are also statistically significant. The horizontal dashed line indicates the threshold for statistical significance, while the vertical dashed lines are the thresholds for biological significance. (B) This figure shows a heatmap generated by RNAdetector with the top 100 differentially expressed small ncRNAs. The top 100 deregulated small ncRNAs were selected for their statistical significance in terms of smaller adjusted p-value. Also with the top 100 deregulated small ncRNAs, CRC and normal tissue samples form two distinct clusters (samples are named with their SRR identifiers). (C) This figure shows a volcano plot generated by RNAdetector in its pathway analysis report with the significantly impacted pathways. All significantly impacted pathways are represented in terms of their measured accumulation (x-axis) and the significance (y-axis). The dotted lines represent the thresholds used to select significantly impacted pathways. Significantly impacted pathways with positive accumulation are shown in red, while the negative ones in blue