Table 7.
Summary data of macroscopic examination for healthy Beagle dogs treated with enflicoxib orally once a week for up to 7 months
| Treatment group | 0X | 1X | 3X | 5X |
|---|---|---|---|---|
| Dose (loading+maintenance) | (Placebo) | (8 + 4 mg/kg) | (24 + 12 mg/kg) | (40 + 20 mg/kg) |
| Adrenals | ||||
| Enlarged | 0 | 0 | 0 | 1 |
| Colon | ||||
| Dark area(s) | 0 | 0 | 1 | 0 |
| Epididymides | ||||
| Unilaterally Absent | 0 | 0 | 1 | 0 |
| Jejunum | ||||
| Abnormal colour | 1 | 0 | 0 | 0 |
| Dark area(s) | 0 | 0 | 0 | 1 |
| Depression(s) | 1 | 1 | 0 | 0 |
| Kidneys | ||||
| Abnormal Colour | 0 | 0 | 0 | 1 |
| Liver | ||||
| Enlarged | 0 | 0 | 0 | 1 |
| Lungs and Bronchi | ||||
| Abnormal colour | 0 | 0 | 0 | 1 |
| Firm | 0 | 0 | 0 | 1 |
| Incomplete deflation | 0 | 0 | 0 | 1 |
| Pale area(s) | 0 | 0 | 0 | 1 |
| Lymph Node, Mesenteric | ||||
| Dark | 0 | 0 | 0 | 1 |
| Pituitary | ||||
| Cyst(s) | 0 | 0 | 0 | 1 |
| Spleen | ||||
| Abnormal Shape | 0 | 0 | 0 | 1 |
| Adhesions | 0 | 0 | 0 | 1 |
| Capsule Thickened | 0 | 0 | 0 | 1 |
| Stomach | ||||
| Dark area(s) | 0 | 0 | 0 | 1 |
| Thyroids | ||||
| Small | 0 | 0 | 0 | 1 |
| Uterus | ||||
| Serosal cyst(s) | 0 | 0 | 0 | 1 |
N = 4 animals/sex/group