Table 1.
Patient characteristics of all included patients and each S100A4 group
| Variables | All patients n = 162 |
S100A4 high group n = 50 |
S100A4 low group n = 112 |
P value |
|---|---|---|---|---|
| Age, years (IQR) | 74 (69–78) | 72 (66–76) | 74 (69–80) | 0.136 |
| Sex, male (%) | 133 (82.1%) | 44 (88.0%) | 89 (79.5%)/ | 0.177 |
| Respiratory function | ||||
| FVC (L) (IQR) | 2.90 (2.34–3.39) | 2.99 (2.44–3.56) | 2.88 (2.30–3.36) | 0.317 |
| VC (L) (IQR) | 2.93 (2.40–3.37) | 3.03 (2.50–3.51) | 2.89 (2.34–3.25) | 0.330 |
| %VC (%) (IQR) | 92.2 (81.1–101.4) | 92.4 (79.3–102.3) | 92.2 (82.8–101.4) | 0.701 |
| %DLCO (%) (IQR) | 54.9 (44.6–68.1) | 57.7 (43.2–76.6) | 53.7 (44.8–67.6) | 0.360 |
| Serum KL-6 (U / ml) (IQR) | 443 (290–739) | 473 (272–945) | 437 (317–660) | 0.065 |
| Collagen disease (%) | 12 (7.4%) | 5 (10.0%) | 7 (6.3%) | 0.411 |
| Preoperative steroid use (%) | 11 (6.8%) | 5 (10.0%) | 6 (5.4%) | 0.293 |
| Radiologic IP pattern | 0.836 | |||
| UIP pattern (%) | 54 (33.3%) | 18 (36.0%) | 36 (32.1%) | |
| Possible UIP pattern (%) | 75 (46.3%) | 23 (46.0%) | 52 (46.4%) | |
| Inconsistent with UIP Pattern (%) | 33 (20.4%) | 9 (18.0%) | 24 (21.4%) | |
| Clinical stage | 0.144 | |||
| 0 (%) | 4 (2.5%) | 0 (0%) | 4 (3.6%) | |
| I (%) | 128 (79.0%) | 42 (84.0%) | 86 (76.8%) | |
| II (%) | 21 (13.0%) | 4 (8.0%) | 17 (15.2%) | |
| III (%) | 9 (5.6%) | 4 (8.0%) | 5 (4.5%) | |
| Histology | 0.867 | |||
| Adenocarcinoma (%) | 65 (40.1%) | 20 (40.0%) | 45 (40.2%) | |
| Squamous cell Carcinoma (%) | 62 (38.3%) | 18 (36.0%) | 44 (39.3%) | |
| Others (%) | 35 (21.6%) | 12 (24.0%) | 23 (20.5%) | |
| Surgical procedure | 0.494 | |||
| Wedge resection (%) | 48 (29.6%) | 12 (24.0%) | 36 (32.1%) | |
| Segmentectomy (%) | 34 (21.0%) | 13 (26.0%) | 21 (18.8%) | |
| Lobectomy (%) | 79 (48.8%) | 25 (50.0%) | 54 (48.2%) | |
| Pneumonectomy (%) | 1 (0.6%) | 0 (0%) | 1 (0.9%) | |
| Operative time (min) (IQR) | 148 (107–190) | 160 (121–207) | 139 (104–182) | 0.069 |
| Pathological stage | 0.460 | |||
| I | 118 (72.8%) | 35 (70.0%) | 83 (74.1%) | |
| II | 26 (16.0%) | 8 (16.0%) | 18 (16.1%) | |
| III | 17 (10.5%) | 6 (12.0%) | 11 (9.8%) | |
| IV | 1 (0.6%) | 1 (2.0%) | 0 (0%) | |
S100A4 S100 calcium-binding protein A4, IQR interquartile range, FVC forced vital capacity, VC vital capacity, DLCO diffusing capacity for carbon monoxide, KL-6 krebs von den lungen-6, IP interstitial pneumonia, UIP usual interstitial pneumonia