Table 3.

Univariable and multivariable analysis of risk factor of acute exacerbation of interstitial pneumonia

	Univariable analysis		Multivariable analysis
	OR (95%CI)	P value	OR (95%CI)	P value
S100A4 high (≥ 17.13 ng/ml)	21.39 (4.64–98.64)	< 0.001	42.28 (3.98–449.29)	0.002
Male	N/A*	0.010	N/A*	0.033
Collagen disease	0.82 (0.10–6.79)	0.852	0.01 (0.01–4.57)	0.141
%VC (≤ 80%)	4.21 (1.46–12.20)	0.008	10.20 (1.26–82.26)	0.029
DLCO (≤ 40%)	2.62 (0.83–8.31)	0.102	5.61 (0.30–103.97)	0.246
Preoperative steroid use	2.17 (0.43–11.08)	0.350	6.29 (0.22–180.26)	0.283
Radiologic UIP pattern	3.37 (1.13–10.02)	0.029	5.13 (0.624–42.22)	0.128
KL-6 (≥ 1000)	4.81 (1.43–16.26)	0.011	1.48 (0.09–24.59)	0.786
Operative time (continuous value)	1.01 (1.00–1.02)	0.048	1.03 (1.01–1.04)	0.001
Anatomical resection	1.27 (0.39–4.14)	0.694	3.21 (0.33–31.37)	0.315

OR odds ratio, CI confidence interval, S100A4 S100 calcium-binding protein A4, N/A not available, VC vital capacity, DLCO diffusing capacity for carbon monoxide, UIP usual interstitial pneumonia, KL-6 krebs von den lungen-6

*OR could not be calculated because none of female patients experienced AE of IP