Table 2.
Nucleotide differences between TB40/EF and TB40/EE within coding regions
| Gene | Protein | Position* | Sequence | Consequence | Prevalence (%)† | |
|---|---|---|---|---|---|---|
| TB40/EF | TB40/EE | |||||
| UL26 | UL26 | 32,663§ | C | E98 | 47 | 0 |
| T | K98 | 53 | 100 | |||
| UL69 | UL69 | 100,074 | G | H492 | 66 | 48 |
| C | Q492 | 44 | 52 | |||
| UL122 | IE2 | 171,008 | C | D390 | 95 | 13 |
| G | H390 | 5 | 87 | |||
| UL128 | UL128 | 175,937§ | A | changes stop codon to Leu | 30 | 0 |
| C | wild-type | 70 | 100 | |||
| 176,044 | TC | deletion introduces a frameshift after codon 135 | 56 | 0 | ||
| wild-type | 44 | 100 | ||||
| UL130 | UL130 | 176,753§ | G | S207, disrupts disulfide bond with C176 | 9 | 0 |
| C | C207, forms disulfide bond with C176 | 91 | 100 | |||
| UL141 | UL141 | 184,933 | wild-type | 56 | 31 | |
| TA | insertion introduces a frameshift after codon 63 | 44 | 69 | |||
| US28 | US28 | 227,251§ | T | C320 | 12 | 0 |
| G | W320 | 88 | 100 | |||
*Coordinates refer to TB40/EF
†Percentage of reads containing the variant
§The consensus sequences for TB40/EF and TB40/EE are identical at this locus