Table 2.
Risk of head and neck cancer according to MS and its components
| No of cases/person-years | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | HR (95%CI) | P | ||
| Presence of MS | |||||||
| No | 495/ 2201184 | Reference | Reference | Reference | |||
| Yes | 311/ 910374 | 1.27[1.10, 1.47] | 0.001 | 1.18[1.02, 1.36] | 0.023 | 1.05[0.90, 1.22] | 0.560 |
| No. of MS components | |||||||
| 0–2 | 483/2167132 | Reference | Reference | Reference | |||
| 3 | 191/582520 | 1.25[1.06, 1.48] | 0.009 | 1.14[0.96, 1.35] | 0.126 | 1.04[0.88, 1.24] | 0.645 |
| 4 | 95/283291 | 1.26[1.01, 1.57] | 0.043 | 1.16[0.93, 1.45] | 0.187 | 1.00[0.80, 1.26] | 0.978 |
| 5 | 37/78614 | 1.70[1.22, 2.38] | 0.002 | 1.58[1.13, 2.21] | 0.008 | 1.30[0.92, 1.84] | 0.132 |
| Center obesity | |||||||
| No | 500/2065978 | Reference | Reference | Reference | |||
| Yes | 304/1036668 | 1.10[0.95, 1.26] | 0.211 | 1.19[1.04, 1.38] | 0.015 | 1.04[0.90, 1.21] | 0.592 |
| Dyslipidemia for TG | |||||||
| No | 141/845849 | Reference | Reference | Reference | |||
| Yes | 665/2262915 | 1.31[1.13, 1.51] | <0.001 | 1.06[0.91, 1.23] | 0.461 | 0.95[0.81, 1.10] | 0.472 |
| Dyslipidemia for HDL-C | |||||||
| No | 301/1501095 | Reference | Reference | Reference | |||
| Yes | 464/1438442 | 1.16[0.98, 1.39] | 0.091 | 1.17[0.98, 1.39] | 0.087 | 1.01[0.84, 1.22] | 0.877 |
| Hypertention | |||||||
| No | 528/2095502 | Reference | Reference | Reference | |||
| Yes | 160/568287 | 1.23[1.02, 1.48] | 0.027 | 1.02[0.84, 1.22] | 0.874 | 1.00[0.82, 1.20] | 0.973 |
| Hyperglycemia | |||||||
| No | 529/2226708 | Reference | Reference | Reference | |||
| Yes | 174/459089 | 1.35[1.14, 1.61] | 0.001 | 1.26[1.06, 1.5] | 0.009 | 1.22[1.02, 1.45] | 0.028 |
Model 1: unadjusted
Model 2: age and gender-stratified model
Model 3: additionally adjusted for education, ethnic, index of multiple deprivation, alcohol consumption, smoking status, physical activity, fruit and vegetable intake, NASIDS use and CRP