Table 5.
Risk of head and neck cancer according to CRP and the joint effect of MS and CRP
| No. of cases/person-years | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | ||
| CRP | |||||||
| < 1.00 mg/dL | 223/1155432 | Reference | Reference | Reference | |||
| ≥ 1.00 mg/dL | 531/1750092 | 1.39[1.18, 1.62] | <0.001 | 1.44[1.23, 1.68] | <0.001 | 1.21[1.03, 1.42] | 0.021 |
| Joint effect of MS and CRP | p-interaction=0.501 | ||||||
| No MS/CRP < 1.00 mg/dL | 181/1027524 | Reference | Reference | Reference | |||
| No MS/CRP ≥ 1.00 mg/dL | 327/1153876 | 1.42[1.19, 1.72] | <0.001 | 1.45[1.21, 1.73] | <0.001 | 1.22[1.02, 1.47] | 0.033 |
| MS/CRP < 1.00 mg/dL | 42/127908 | 1.50[1.07, 2.10] | 0.018 | 1.30[0.93, 1.82] | 0.126 | 1.20[0.85, 1.68] | 0.298 |
| MS/CRP ≥ 1.00 mg/dL | 204/596216 | 1.58[1.29, 1.93] | <0.001 | 1.61[1.31, 1.96] | <0.001 | 1.29[1.05, 1.58] | 0.017 |
Model 1: unadjusted
Model 2: age and gender-stratified model
Model 3: additionally adjusted for education, ethnic, index of multiple deprivation, alcohol consumption, smoking status, physical activity, fruit and vegetable intake, and NASIDS use