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. 2021 Jun 3;22:299. doi: 10.1186/s12859-021-04199-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Deferentially enriched species between the OA patients and their controls. For selected different species, the orientation of enrichment was determined by partial correlation test (p < 0.05, Additional file 1: Table S4). Size of the nodes consistent with the relative abundance of species. Species were colored according to enrichment. Edges between nodes indicated positive (ginger) and negative (blue) Spearman’s correlation. The line thickness represents the correlation coefficient which calculated according to the samples under comparison (a). Receiver operating characteristic curve (ROC) according to 114 samples of the discovery set from 57 OA patients and 57 HCs (green line) calculated by Cross-validated random forest models. Area under ROC (AUC) and the 95% confidence interval are also shown (b). The height of the column indicates the contribution of the species to the discriminative model (c). The relative abundance and significance of 9 species in OA classifier (d)