Table 1.
Differentially enriched gut metabolic modules (GMMs) in OA patients and healthy controls (adjusted the age and BMI by Partial correlation test, P value < 0.05); whole GMMs please refer to Additional file 1: Table S5)
| GMMs | p value | Q value | Enrichment |
|---|---|---|---|
| Tryptophan degradation | 0.0021 | 0.0949 | Healthy Controls < OA patients |
| Glutamine degradation I | 0.0048 | 0.0949 | Healthy Controls < OA patients |
| Tyrosine degradation II | 0.0191 | 0.1462 | Healthy Controls < OA patients |
| Propionate production III | 0.0194 | 0.1562 | Healthy Controls < OA patients |
| Acetate to acetyl-coa | 0.0391 | 0.1768 | Healthy Controls < OA patients |
| Triacylglycerol degradation | 0.0033 | 0.0949 | OA patients < Healthy Controls |
| Formate conversion | 0.0048 | 0.0991 | OA patients < Healthy Controls |
| Glycerol degradation I | 0.0060 | 0.0982 | OA patients < Healthy Controls |
| Bifidobacterium shunt | 0.0060 | 0.0949 | OA patients < Healthy Controls |
| Glycerol degradation II | 0.0061 | 0.0949 | OA patients < Healthy Controls |
| Pentose phosphate pathway (non-oxidative branch) | 0.0066 | 0.0949 | OA patients < Healthy Controls |
| Methionine degradation I | 0.0081 | 0.1520 | OA patients < Healthy Controls |
| Homoacetogenesis | 0.0084 | 0.0949 | OA patients < Healthy Controls |
| Methionine degradation II | 0.0192 | 0.1562 | OA patients < Healthy Controls |
| Methanogenesis from carbon dioxide | 0.0233 | 0.1768 | OA patients < Healthy Controls |
| Cysteine biosynthesis/homocysteine degradation | 0.0241 | 0.1768 | OA patients < Healthy Controls |
| Acetyl-coa to acetate | 0.0252 | 0.1591 | OA patients < Healthy Controls |
| Fructose degradation | 0.0343 | 0.1520 | OA patients < Healthy Controls |
| Serine degradation | 0.0365 | 0.1768 | OA patients < Healthy Controls |
| Methanogenesis-methyl-com | 0.0387 | 0.2107 | OA patients < Healthy Controls |
| Glycolysis (preparatory phase) | 0.0445 | 0.1878 | OA patients < Healthy Controls |
| Fucose degradation | 0.0454 | 0.2211 | OA patients < Healthy Controls |
| Glutamine degradation II | 0.0467 | 0.2107 | OA patients < Healthy Controls |
| Glycolysis (pay-off phase) | 0.0476 | 0.1768 | OA patients < Healthy Controls |
| Hydrogen metabolism | 0.0496 | 0.3106 | OA patients < Healthy Controls |
The p value was calculated by Wilcoxon rank sum test, the Q value was the p value adjusted by Benjamini–Hochberg. Enrichment means the relative abundance of the related GMMs in the healthy controls and the OA patients