Table 4.
Postoperative outcomes patients receiving opioid-free anaesthesia (OFA) and opioid-based anaesthesia (OBA)
| All patients (n = 80) | OFA (n = 40) | OBA (n = 40) | P-value | |
|---|---|---|---|---|
| PaO2/FiO2 ratio at ICU arrival | 309 ± 99 | 327 ± 112 | 291 ± 81 | 0.10 |
| Lowest PaO2/FiO2 ratio during first 48 h | 238 [188–278] | 244 [189–288] | 226 [186–273] | 0.49 |
| Noninvasive ventilation use | 29 (36) | 10 (25) | 19 (48) | 0.04 |
| Time to extubation, hours | 3 [2–5] | 2 [2–3] | 4 [2–7] | < 0.01 |
| Reintubation | 4 (5) | 2 (5) | 2 (5) | 1.00 |
| Vomiting and/or nausea | 8 (10) | 3 (8) | 5 (13) | 0.71 |
| Surgical re-exploration | 7 (9) | 1 (3) | 6 (15) | 0.11 |
| Need for vasopressors ≥6 h | 23 (29) | 13 (33) | 10 (25) | 0.46 |
| Need for inotropes ≥6 h | 9 (11) | 4 (10) | 5 (13) | > 0.99 |
| New onset of atrial fibrillation | 23 (29) | 7 (18) | 16 (40) | 0.03 |
| Ventricular arrhythmias* | 5(6) | 2 (5) | 3 (8) | > 0.99 |
| Atrioventricular block£ | 1 (1) | 0 | 1 (3) | > 0.99 |
| Delirium | 8 (10) | 1 (3) | 7 (18) | 0.06 |
| ARF (KDIGO stage 2 or 3) | 5 (6) | 1 (3) | 4 (10) | 0.36 |
| Hs-cTnI at 12 h, ng. L−1 | 1700 [918–4925] | 1700 [900–3500] | 1700 [1000–8200] | 0.44 |
| ICU length of stay, hours | 48 [41–73] | 47 [35–84] | 49 [42–73] | 0.55 |
| Hospital length of stay, days | 12 [9–15] | 11 [10–15] | 13 [9–15] | 0.48 |
Data are presented as median [Interquartile range] or mean ± standard deviation or number (%) of patients. ICU intensive care unit, * ventricular or fibrillation, £ high-grade atrioventricular block requiring pacemaker implantation, ARF acute renal failure, KDIGO Kidney Disease Improving Global Outcomes, Hs-cTnI high-sensitivity cardiac troponin I. P value refers to comparison between OFA and OBA groups