Table 3.

Effect estimate for impact of methamphetamine-associated PAH on functional capacity

Outcome	Mean Difference (95% CI)	P Value
Unadjusted
World Health Organization functional class	0.15 (0.01 to 0.29)	0.032
Six minute walk distance, m	34.31 (8.96 to 59.66)	0.008
Adjusted for age alone
World Health Organization functional class	0.22 (0.08 to 0.36)	0.002
Six minute walk distance, m	6.6 (−18.8 to 32.1)	0.610
Adjusted for age, sex, race/ethnicity, education, and the time-dependent covariates of body mass index and whether the participant was on PAH-specific therapy or not
World Health Organization functional class	0.22 (0.07 to 0.37)	0.004
Six-minute walk distance, m	9.5 (−16.5 to 35.5)	0.474

Definition of abbreviations: CI = confidence interval; PAH = pulmonary arterial hypertension.

Data are presented as mean difference with 95% CIs between participants with methamphetamine-associated PAH as compared with participants with idiopathic PAH, as quantified by generalized estimating equations using a Gaussian distribution. This represents the adjusted mean increase in outcome over the entire study that is seen in participants with methamphetamine-associated PAH as compared with those with idiopathic PAH. Models adjusted for age, sex, race/ethnicity, education, and the time-dependent covariates of body mass index and whether the participant was on PAH-specific therapy or not.