Table 2.

Post-KA chronic epilepsy in rats

Administration mode	SE	Latent period	SRS	Comorbidities	References
Systemic	Starts within 2 h Lasts for 5–9 h 22% mortality	12–36 d	8 per day (±5.4)	Cognitive impairment Aggressiveness	Stafstrom et al. (1992) Lado (2006) Williams et al. (2009) Drexel et al. (2012) Bertoglio et al. (2017)
ICV	Starts within 10–30 min Lasts for 2–6 h <10% mortality	7–14 d	5 per day (±3.5)	Cognitive impairment	Miyamoto et al. (1997) Jing et al. (2009) Gordon et al. (2014) Song et al. (2016) Gao et al. (2019)
Intra-HC	Starts within 5–20 min Lasts for 3–15 h <5% mortality	13–30 d	8 per day (±6.3)	Cognitive impairment Perseverative behavior Hyperexcitability	Cavalheiro et al. (1982) Bragin et al. (2005) Arkhipov et al. (2008) Rattka et al., 2013) Klee et al. (2017)
Intra-Am	Starts within 5–30 min Lasts for 4–6 h 10% mortality	11–24 d	12 per day (±6.2)	No data	Ben-Ari et al. (1979) Tanaka et al. (1992) Ueda et al. (2001) Takebayashi et al. (2007) Gurbanova et al. (2008)

Am, amygdala; HC, hippocampus; ICV, intraventricular; SE, status epilepticus; SRS, spontaneous recurrent seizures