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Tumor imaging with anti-EGFR-PEG-SPIONs. T2WI MRI images a) and SNR b) of tumor after injection of 0.1 mL targeted and nontargeted contrast agents at different time points (0.5, 1, 4, 6, 10, 12 h). The mean T2-weighted signal intensities were measured for each tumor. The relative SNR was calculated. Prussian blue staining of tumor tissues after 6 h injection of c) anti-EGFR-PEG-SPIONs and d) PEGylated SPIONs. Reproduced with permission.[135] Copyright 2017, Elsevier.
