Table 3.

Overexpressed integrins and associated phenotypes in some human tumors.

Tumor type	Integrins expressed	Major associated consequence	Reference
LCBMa)	αvβ6 and αvβ3	High expression in endothelial cells, low expression in tumor cells	[85]
Prostate	αvβ3 and αvβ5	High expression in peri-tumoral tissue depending on differentiation	[86]
Breast	α6β4 and αvβ3	Correlated with increased tumor size and grade and decreased survival (α6β4). Increased bone metastasis (αvβ3)	[87]
Pancreatic	αvβ3	Lymph node metastasis	[88]
Glioblastoma	αvβ3 and αvβ5	Both expressed at the tumor-normal tissue margin with a possible role in invasion	[89]
Ovarian	α4β1 and αvβ3	Increased peritoneal metastasis (α4β1) and tumor proliferation (αvβ3).	[90]
Cervical	αvβ3 and αvβ6	Decreased patient survival	[91]
NSCLCb)	α5β1	Decreased survival in patients with lymph node-negative tumors.	[92]
Melanoma	αvβ3 and α5β1	Vertical growth phase and lymph node metastasis	[93]
Liver	αvβ6	Differentiates cholangiocarcinoma from hepatocellular carcinoma	[94]
Colon	αvβ6	Reduced patient survival	[95]

^a)Lung cancer brain metastases;

^b)Non-small-cell lung carcinoma.